White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs

P Klauser; ST Baker; VL Cropley; C Bousman; A Fornito; L Cocchi; JM Fullerton; P Rasser; U Schall; F Henskens; PT Michie; C Loughland; SV Catts; B Mowry; TW Weickert; C Shannon Weickert; V Carr; R Lenroot; C Pantelis; A Zalesky

Journal article

White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs

P Klauser, ST Baker, VL Cropley, C Bousman, A Fornito, L Cocchi, JM Fullerton, P Rasser, U Schall, F Henskens, PT Michie, C Loughland, SV Catts, B Mowry, TW Weickert, C Shannon Weickert, V Carr, R Lenroot, C Pantelis, A Zalesky

Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2017

DOI: 10.1093/schbul/sbw100

Abstract

White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across studies is moderate. In this study, neuroimaging was used to investigate white matter pathology and its impact on whole-brain white matter connectivity in one of the largest samples of patients with schizophrenia. Fractional anisotropy (FA) and mean diffusivity (MD) were compared between patients with schizophrenia or schizoaffective disorder (n = 326) and age-matched healthy controls (n = 197). Between-group differences in FA and MD were assessed using voxel-based analysis and permutation testing. Automated whole-brain white matter fiber tracking and the network-ba..

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University of Melbourne Researchers

Paul Klauser Author

Vanessa Cropley Author

Christos Pantelis Author

Andrew Zalesky Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Swiss Society for Medicine and Biology

Awarded by NHMRC

Awarded by Brain and Behavior Research Foundation (NARSAD)

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This study used samples and data from the Australian Schizophrenia Research Bank (ASRB), funded by a National Health and Medical Research Council (NHMRC) Enabling Grant (386500) held by V. Carr, U. Schall, R. Scott, A. Jablensky, B. Mowry, P. Michie, S. Catts, F. Henskens, and C. Pantelis (Chief Investigators), and the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute, using an infrastructure grant from the NSW Ministry of Health. P.K. was supported by the Swiss National Science Foundation (SNSF) and the Swiss Society for Medicine and Biology Scholarships (148384) and the National Center for Competence in Research-SYNAPSY-funded by the SNSF. V.C. was supported by a NHMRC Early Career Fellowship (628880) and a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660). C.B. was supported by a Brain and Behavior Research Foundation (NARSAD) Young Investigator Grant (20526) and University of Melbourne Ronald Phillip Griffith Fellowship. A.F. was supported by an Australian Research Council Future Fellowship (FT130100589) and NHMRC Project Grants (1050504, 1066779). L.C. was supported by a NHMRC Project Grant (APP1099082). J.M.F. was supported by the Janette Mary O'Neil Fellowship and NHMRC (1063960). C.S.W. was supported by Schizophrenia Research Institute (utilizing infrastructure funding from the NSW Ministry of Health and the Macquarie Group Foundation), the University of New South Wales, Neuroscience Research Australia, and by a NHMRC Senior Research Fellowship (1021970). C.P. was supported by a NHMRC Senior Principal Research Fellowship (628386, 1105825), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (18722). A.Z. was supported by a NHMRC Career Development Fellowship (GNT1047648).